According to substance effects, which drug is associated with increased appetite?

Marijuana is known for its association with increased appetite, often referred to as "the munchies." This effect occurs primarily due to the interaction of cannabinoids, particularly THC (tetrahydrocannabinol), with the body’s endocannabinoid system. When THC binds to the CB1 receptors in the brain, it can stimulate the release of hormones that boost appetite and enhance the sensory experience of eating, making food taste better and more enjoyable. This is why many individuals report a significant increase in their desire to eat after using marijuana.

In contrast, other substances do not typically enhance appetite in the same way. Caffeine, for instance, may suppress appetite in some users temporarily, while narcotics can alter the perception of hunger but often lead to decreased appetite over time due to their sedative effects. Ecstasy (MDMA) is generally not associated with increased appetite and is more likely to lead to appetite suppression during its effects.