Cross-dependence occurs when:

Cross-dependence specifically refers to a phenomenon where the withdrawal symptoms from one drug can be alleviated by using another drug that belongs to the same classification or has similar effects on the body. This is commonly observed in substances like opioids or benzodiazepines, where an individual may experience withdrawal from one substance but find that taking another substance in the same category helps reduce their symptoms.

Understanding cross-dependence is crucial in addiction treatment and management because it highlights the potential for using one drug as a substitute for another to ease withdrawal, which can complicate recovery efforts. This concept underscores the need for careful monitoring and management when prescribing medications, particularly in individuals with a history of substance use disorders.

The other options describe different concepts related to substance use and dependence, but they do not accurately capture the essence of cross-dependence as it is understood within the context of pharmacology and addiction.