How does Disulfiram (Anatabuse) deter alcohol consumption?

Disulfiram, commonly known as Antabuse, deters alcohol consumption primarily by inhibiting the enzyme acetaldehyde dehydrogenase. This action leads to an accumulation of acetaldehyde, a toxic metabolite of alcohol, when alcohol is consumed. The buildup of acetaldehyde results in unpleasant effects such as flushing, nausea, vomiting, and palpitations, which serve as a strong deterrent for individuals considering drinking alcohol while on this medication.

This pharmacological approach effectively creates an aversive reaction to alcohol, reinforcing the reasons to abstain from drinking. Understanding the mechanism of disulfiram helps in recognizing its role in the treatment of alcohol use disorder, as it capitalizes on the negative physical responses associated with alcohol consumption when disulfiram is taken.