In which scenario does reverse tolerance occur?

Reverse tolerance, often referred to as sensitization, occurs when a user experiences an increased sensitivity to a substance after repeated use, which can lead to a stronger effect from the same dose of the drug. This heightened sensitivity can happen even after a period of abstinence, where users might find that lower doses produce effects that they previously needed higher doses to achieve.

This scenario contrasts with the typical pattern of tolerance, where increased use results in a diminished response to the drug. In reverse tolerance, rather than requiring more of the substance to achieve the same effects, the individual's body becomes more responsive, thus necessitating less of the substance for the desired outcome.