Tolerance to a drug is indicated by what phenomenon?

Tolerance to a drug is a phenomenon where an individual requires a higher dose of the drug to achieve the same effect that they initially experienced at a lower dose. This happens due to changes in the body’s response to the drug over time, often because of physiological adaptations. For example, when a person regularly uses a substance, their body may become more efficient at metabolizing it or may adjust receptor sensitivities, leading to a diminished response to the same amount of the drug. Consequently, in order to achieve the desired effect, a person must increase the dosage.

This understanding is critical in the context of substance use and dependence, as tolerance can be a key indicator of developing a problematic relationship with a substance. If an individual finds that they need to consume more of a drug to experience its effects, it may signal a shift in their body’s interaction with the drug, thereby raising concerns about potential dependency or abuse.