What can be a dangerous consequence of combining barbiturates with other depressants?

The option identifying synergistic effects that can produce death as a consequence of combining barbiturates with other depressants is correct because barbiturates, when taken with other central nervous system depressants like alcohol or benzodiazepines, can significantly amplify their sedative effects. This potent combination can lead to severe respiratory depression, decreased heart rate, or even coma and death due to the compounded effects on the body's vital functions.

Combining substances that depress the central nervous system creates a Risk of overdose, as the user may underestimate how much they can safely consume when mixing these drugs. Therefore, understanding the dangerous interactions between barbiturates and other depressants is crucial for patient safety and prevention of fatal outcomes.