What does dependence on a substance generally indicate?

Dependence on a substance generally indicates a consistent struggle to stop or reduce use. This condition is characterized by the development of tolerance, where an individual needs more of the substance to achieve the same effects, and withdrawal symptoms when they try to reduce or stop consumption. These factors demonstrate a level of psychological and physical reliance on the substance, which can lead to significant distress and functional impairment in various areas of life.

This consistent struggle indicates that the individual's relationship with the substance has moved beyond casual use into a more problematic pattern, often requiring intervention or treatment to address the dependence effectively. Genuine dependence means that an individual may attempt to quit but finds it challenging due to cravings, physiological withdrawal, or ingrained habits developed over time.