What does tolerance refer to in drug use?

Tolerance in drug use refers to the phenomenon where a person's response to a drug diminishes over time with repeated exposure. This means that as a person continues to use a substance, they may find that they need to consume larger amounts of it to achieve the same effect they initially experienced. This occurs because the body becomes accustomed to the presence of the drug, leading to physiological adaptations that reduce its effects.

Understanding tolerance is crucial in the context of substance use, as it can lead to increased consumption and a higher risk of dependency or addiction. This concept also underscores the importance of monitoring drug use and seeking appropriate treatment or intervention when necessary, as escalating dosage can result in serious health concerns.