What effect does tolerance have on drug users?

Tolerance is a physiological phenomenon where the body's response to a drug decreases with repeated use, leading to users needing to consume higher doses to achieve the same effects they initially experienced. This adaptation occurs because the body becomes more efficient at metabolizing the substance or because it adjusts its receptors, reducing the drug's impact over time. As a result, individuals may escalate their consumption to obtain the desired effects, which can raise the risk of overdose, dependence, and various health issues.

The concept of tolerance is crucial in understanding substance use disorders and informs treatment approaches, as it highlights the importance of monitoring dosages and understanding the risk-benefit ratio when managing patients with a history of substance use.