What is a major concern with the use of sedatives?

The primary concern with the use of sedatives is indeed the potential for death due to the suppression of breathing. Sedatives are central nervous system depressants that can lower the body's respiratory rate. In cases of overdose or when combined with other depressants (such as alcohol or opioids), the risk of respiratory failure significantly increases. This suppression can lead to inadequate oxygen supply to the body, resulting in severe health consequences, including death.

While the development of high tolerance and acute euphoria can also be associated with sedative use, they are not the most immediate or severe risks like respiratory depression. Tolerance can develop over time, leading individuals to take larger doses, which may further increase the risk of respiratory suppression. Acute euphoria may occur as a side effect but does not pose a direct danger to life in the same way that suppression of breathing does. Extreme hyperactivity is generally not a common effect of sedatives, as they are designed to relax and calm the central nervous system rather than stimulate it.