What is an acute effect of MDMA regarding physical condition?

MDMA, commonly known as ecstasy, has several acute effects on physical condition, one of the most significant being hyperthermia. This is a condition in which the body's temperature rises to dangerous levels, often exceeding 104 degrees Fahrenheit (40 degrees Celsius). The use of MDMA can lead to increased physical activity, particularly in club or party environments, which can contribute to this rise in body temperature. Additionally, MDMA causes the release of serotonin and other neurotransmitters that can alter the body's thermoregulation processes, leading to further increases in core temperature.

This effect poses serious health risks, including heat stroke and dehydration, making it a crucial aspect to be aware of when discussing the acute effects of MDMA.