What is known about the mechanism of action of Acamprosate?

Acamprosate's mechanism of action primarily involves balancing the neurotransmitter systems that are disrupted by chronic alcohol use, particularly focusing on the glutamatergic and GABAergic systems. This does not mean that its action is entirely understood, as there are still aspects of its pharmacological profile that warrant further research. The drug specifically helps to stabilize the mood and reduce cravings associated with alcohol withdrawal, thus contributing to a decrease in withdrawal symptoms. This is important for individuals who are trying to maintain sobriety after detoxification.

While it is noted that Acamprosate may have some impact on mood and stabilization of brain chemistry, the primary function tied to its clinical use is the support it provides during the abstinence phase by lessening the discomfort of withdrawal, which aids in recovery efforts. Acamprosate does not have a known role in stimulating appetite or enhancing sleep, making the reduction of withdrawal symptoms a significant focus in understanding its clinical application.