What is reverse tolerance in relation to drug effects?

Reverse tolerance refers to a phenomenon where an individual becomes increasingly sensitive to the effects of a drug over time, even if they have been using it regularly. This can occur for various reasons, such as changes in the body’s chemistry or alterations in how the brain responds to the substance. As a result, a lower dose of the drug can lead to more pronounced or undesirable effects compared to previous use.

Understanding reverse tolerance is important in the context of substance use, as it can impact treatment approaches and highlight the need for careful monitoring of dosage and effects. This concept distinguishes itself from the typical pattern of tolerance, where higher amounts of a drug are required to achieve the same effect.