What method did Sakel use in 1933 to help schizophrenic patients?

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Sakel's use of insulin therapy in 1933 for treating schizophrenic patients marked a significant development in psychiatric treatment. The method involved administering insulin to induce a state of hypoglycemia, which could lead to a temporary coma. This therapeutic approach was grounded in the belief that the extreme physiological response could reset or rejuvenate a patient's mental state.

Insulin therapy was based on the premise that the shock of the bodily changes could somehow alleviate symptoms of schizophrenia. Many practitioners at the time noted varying levels of improvement in some patients, which contributed to the initial acceptance of the treatment within psychiatric settings. This intervention was particularly notable at a time when other forms of treatment were still limited and often less understood.

While electroconvulsive therapy, psychoanalysis, and behavioral therapy have all played roles in the treatment of various mental health conditions, they either emerged later or did not align with the specific historical context of Sakel's work in treating schizophrenia through insulin therapy. Thus, the effectiveness and method of insulin therapy clearly distinguish it as the correct answer in the context of the question.

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