What occurs after a person ingests alcohol while on Disulfiram?

When a person ingests alcohol while taking Disulfiram, effects that begin shortly after consumption are experienced. Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, which leads to an accumulation of acetaldehyde in the body when alcohol is consumed. This buildup causes unpleasant reactions, commonly referred to as the Disulfiram-alcohol reaction.

Symptoms may include flushing, nausea, vomiting, palpitations, and shortness of breath, and they typically onset rapidly after alcohol ingestion, often within minutes. The goal of Disulfiram is to create a strong aversion to alcohol to assist individuals in maintaining sobriety. The immediate unpleasant effects serve as a deterrent, reinforcing the motivation to abstain from alcohol consumption.

Understanding this reaction underscores the importance of patient education regarding the avoidance of alcohol while on Disulfiram, as the immediate effects can be severe and uncomfortable, further emphasizing the contraindications associated with the medication.