What substances make up a Speedball?

A Speedball is a combination of two specific drugs: heroin and cocaine. This mixture takes advantage of the contrasting effects of both substances, where heroin acts as an opioid that depresses the central nervous system, while cocaine serves as a stimulant that increases activity and alertness. The combination can create a unique and intense high, but also increases the risk of overdose and severe health complications because the user may not accurately gauge the effects of each drug simultaneously.

The choice correctly identifies the two substances that characterize a Speedball, making it pivotal for understanding the risks and interactions associated with their use. Other combinations listed, such as heroin with alcohol or cocaine with amphetamines, do not describe a Speedball and typically involve different pharmacological effects and health risks.