What type of dependence may result from the abuse of Schedule III substances?

The correct answer highlights that the abuse of Schedule III substances can lead to moderate physical dependence or high psychological dependence. Schedule III substances, as classified by the Drug Enforcement Administration (DEA), include medications such as anabolic steroids and certain pain medications. These substances carry a lower risk of abuse compared to those in Schedules I and II but can still result in significant psychological dependence due to their effects on mood and behavior.

Moderate physical dependence might manifest as withdrawal symptoms, even though these symptoms are typically less severe than those from Schedule I and II substances. Additionally, the potential for high psychological dependence stems from the fact that these substances can create cravings and a strong desire to continue use for their pleasurable effects. This dynamic underlines the importance of monitoring and managing the use of Schedule III substances, as they can lead to problematic patterns of use.

In contrast, options suggesting severe physical dependence, low psychological dependence, or no dependence do not accurately reflect the risks associated with these substances, as studies and clinical observations indicate a notable potential for dependence.