Which antidepressants are noted for having low addiction potential in the treatment of comorbid depression?

The choice of imipramine and nortriptyline stands out as noteworthy due to their pharmacological profiles that lend to lower addiction potential compared to other classes of antidepressants. Both imipramine and nortriptyline are tricyclic antidepressants (TCAs), which work primarily by inhibiting the reuptake of norepinephrine and serotonin, thereby enhancing their neurotransmission.

In the context of treating comorbid depression, it is crucial to select medications that not only provide therapeutic benefits but also minimize the risks of addiction or misuse. TCAs like imipramine and nortriptyline are generally regarded as having a lower risk for dependency when used appropriately under medical supervision. This feature may make them a preferable option for patients with depressive symptoms alongside other psychological or substance use disorders.

While other antidepressants could also be effective in managing depression, they may carry a higher potential for misuse or addiction. For instance, bupropion has stimulant-like properties that could lead to misuse in certain individuals. Therefore, imipramine and nortriptyline provide a solid option in the treatment of individuals with comorbid depression and those who may be susceptible to addictive behaviors.