Which neurotransmitters are affected by cocaine and amphetamines?

Cocaine and amphetamines are known to significantly affect the levels of certain neurotransmitters in the brain, primarily dopamine, norepinephrine, and serotonin.

Dopamine is crucially involved in the brain's reward system, and both cocaine and amphetamines increase dopamine levels by inhibiting its reuptake and stimulating its release. This surge in dopamine is primarily responsible for the euphoric effects that users experience, as well as contributing to the substance's addictive properties.

Norepinephrine is also influenced by these substances. Cocaine and amphetamines lead to enhanced levels of norepinephrine, which can result in increased alertness and energy, as norepinephrine plays a role in the body's fight-or-flight response.

Serotonin, while not the primary focus of cocaine and amphetamine action, is nevertheless impacted by both substances. An increase in serotonin levels can affect mood, appetite, and various physiological processes.

Therefore, the correct response indicating that cocaine and amphetamines affect dopamine, norepinephrine, and serotonin captures the comprehensive influence these stimulants have on neurochemical activity in the brain.