Which of the following is NOT a specifier for Substance Dependence?

When considering the criteria for Substance Dependence, it is important to understand the various specifiers that exist for this diagnosis. Specifiers provide additional detail that helps clarify the nature and context of the substance use disorder.

The correct answer, specifying that "with onset during intoxication" is not a recognized specifier for Substance Dependence, is based on the understanding that such a descriptor does not specifically align with the clinical definitions used in diagnosing substance-related disorders. In the context of substance dependence, specifiers like those indicating psychological dependence, remission status, or the individual's living situation (like being in a controlled environment) are meaningful additions that can affect treatment planning and understanding the overall situation of the individual.

Specifically, "with psychological dependence" indicates a reliance on the psychological effects of substances, while "with remission specified" refers to the status of the disorder in terms of active or inactive phases. "In a controlled environment" highlights specific circumstances where substance use is limited by external factors. These are valid and used in clinical practice to describe the varying nuances of substance dependence. The absence of a specification related to onset during intoxication underscores its lack of recognition in clinical vocabulary and diagnostic criteria.