Which of the following is a predisposition factor for Dysthymic Disorder?

A predisposition factor for Dysthymic Disorder, as indicated by the choice of a major loss in childhood, highlights the impact of early life stressors on long-term emotional health. Major losses, such as the death of a parent or significant caregiver, can lead to unresolved grief and emotional disturbances that may contribute to the development of chronic mood disorders like Dysthymic Disorder, which is characterized by persistent low mood and a lack of enthusiasm or motivation.

The significance of early trauma or loss in forming the framework for later mental health issues is well-supported in clinical psychology. Such experiences can negatively affect a person's self-esteem, coping mechanisms, and overall outlook on life, making them more vulnerable to depressive states, including Dysthymia.

The other choices, such as having extensive social support, being physically active, and having a stable job, typically function as protective factors rather than predisposition factors. Social support, physical activity, and job stability can contribute to resilience and a better emotional state, helping to mitigate the risks of developing mood disorders.