Which of the following is NOT one of the three major categories of abused substances requiring detox?

Marijuana is often not classified among the three major categories of abused substances that typically require detox due to its relatively lower physiological dependency potential compared to other substances. The primary need for detox arises from the withdrawal symptoms associated with substances such as alcohol, opiates, and certain central nervous system (CNS) depressants, which can produce significant physical symptoms and can often be life-threatening during withdrawal.

Alcohol and CNS depressants can lead to severe withdrawal symptoms, including delirium tremens, seizures, and other serious complications. Opiate drugs, such as heroin and prescription painkillers, also necessitate detox because their withdrawal symptoms can be extremely uncomfortable and can include pain, gastrointestinal distress, and psychological effects.

In contrast, while marijuana can lead to psychological dependence and withdrawal symptoms, they are generally mild and do not typically require the same level of medical intervention that other substances do. This fundamental difference in the severity of withdrawal and the potential health risks associated with detox explains why marijuana is not categorized alongside the other three major substances that commonly necessitate detoxification.