Which schedule classification represents substances with the highest potential for abuse?

The classification of substances under the Controlled Substances Act categorizes drugs based on their potential for abuse, with Schedule I identified as the category having the highest potential for abuse. Schedule I substances are not accepted for medical use and are deemed to pose an extreme risk of dependence. Common examples of Schedule I drugs include heroin and LSD, which have no accepted medical uses and are associated with a high likelihood of being misused.

In contrast, Schedule II substances do have accepted medical uses, but they also carry a high potential for abuse and may lead to severe psychological or physical dependence. Examples include opioids like oxycodone and narcotics.

Schedules III and IV include substances that are less likely to be abused. Schedule III drugs have moderate potential for dependence, while Schedule IV substances have a lower potential for abuse compared to the higher schedules.

Therefore, Schedule I represents the category with the highest potential for abuse, as it encompasses substances that pose significant risks both in terms of misuse and lack of medical utility.